Sepsis-Associated Encephalopathy: from Pathophysiology to Progress in Experimental Studies

Sepsis is an organ dysfunction caused by uncontrolled inflammatory response from the host to infection. main cause of morbidity and mortality in intensive care units (ICU) worldwide. One first organs suffer injuries resulting sepsis brain. The central nervous system (CNS) particularly vulnerable damage, mediated oxidative processes, which can sepsis-associated encephalopathy (SAE), being reported up 70% septic patients. This review aims bring a summary pathophysiological changes dysfunctions SAE, focuses current experimental studies for new treatments therapies. pathophysiology SAE complex multifactorial, combining intertwined promoted countless alterations sepsis, such as inflammation, neuroinflammation, stress, reduced brain metabolism, integrity blood-brain barrier (BBB). treatment limited once its not completely understood. patient’s sedation far provide adequate this condition. Studies advances are important better understanding development treatments, medicines, therapies reduce effects during after sepsis.